糖原合成酶激酶-3 (Glycogen synthase kinase-3, GSK-3)是一個(gè)多功能的絲氨酸/蘇氨酸蛋白激酶,不僅參與肝糖代謝過程,而且還參與Wnt和Hedgehog信號(hào)通路,通過磷酸化多種底物蛋白來(lái)調(diào)節(jié) 細(xì)胞的生理過程。GSK-3抑制劑作為目前倍受關(guān)注的小分子抑制劑,對(duì)治療神經(jīng)退化性疾病,癌癥具有潛在療效。
GSK-3 抑制劑
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| 目錄 |
產(chǎn)品名稱 |
產(chǎn)品描述 |
| S1263 |
CHIR-99021 (CT99021) |
CHIR 99021是最有效和特定的GSK3抑制劑，IC50為40 nM。 |
| S1075 |
SB 216763 |
SB 216763 inhibited human GSK-3α with IC50s of 34 nM. |
| S2386 |
Indirubin |
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM. |
| S1590 |
TWS119 |
TWS119 is a glycogen synthase kinase-3β inhibitor with an IC50 of 30 nM. |
| S2729 |
SB 415286 |
SB 415286 is a potent and selective cell-permeable, ATP-competitive GSK3α inhibitor with an IC50 and a Ki of 78 and 31 nM, respectively. |